Treatment of recurrent conjunctival papillomatosis with mitomycin C

PURPOSE: To report an effective treatment for recurrent squamous papillomas of the conjunctiva with excision and application of mitomycin C. METHOD: Case report. RESULTS: A 5-year-old African-American girl with recurrent squamous papillo mas of the right bulbar and palpebral conjunctiva was treated with multiple therapies, including excision, cryotherapy, and conjunctival injection of alpha-interferon; all therapies were followed by recurrence. After treatmen t with excision followed by intraoperative application of mitomycin C to th e involved conjunctiva, the patient had no recurrence in a 30-month period. CONCLUSIONS: Excision with application of mitomycin C was successful in man aging a case of squamous papillomatosis that was resistant to traditional t herapy. (C) 1999 by Elsevier Science Inc. All rights reserved.