Leptin response to carbohydrate or fat meal and association with subsequent satiety and energy intake

To assess the impact of the macronutrient content of a meal on the postpran dial leptin response and its relationship with postprandial satiety, 22 you ng healthy subjects (11 men and 11 women) were given, in a randomized order , an isoenergetic meal [carbohydrate (81%) or fat (79%)] or remained fastin g. Blood sampling and hunger and satiety scores were collected hourly durin g 9 h after the meal. Spontaneous intake was measured at a buffet meal at 9 h postprandially. In both genders, leptin response was higher after the ca rbohydrate meal than after the fat meal and while fasting. In women, leptin levels were higher after the fat meal than while fasting. Leptin response was significantly correlated to insulin response (r = 0.51, P < 0.0001). Hu nger and satiety ratings and subsequent energy intake were not different af ter carbohydrate or fat intake. In conclusion, a carbohydrate meal induces higher postprandial leptin levels than an isoenergetic fat meal. Short-term regulation of postprandial satiety and food intake is not influenced by ci rculating leptin.