Recombinant adenoviruses as vectors in vaccination

According to numerous reported studies, recombinant vaccines based on repli cative versus non replicative adenoviruses appear to be attractive candidat es for vaccination against animal and human diseases. They have proven thei r ability to express high levels of heterologous genes and to induce humora l and cellular immunity independently of the antigen, the animal model or t he route of administration, Furthermore, these vectors induce an excellent immunity upon application to mucosal membranes suggesting their usefulness as vaccines against different infectious agents responsible for respiratory and genital diseases.