Evaluation of transmyocardial laser revascularization (TMLR) by gated myocardial perfusion scintigraphy

TMLR is a novel treatment for patients with coronary artery disease. It com prises the creation of transmyocardial channels thought to improve myocardi al perfusion. Gated Tc-99m sestamibi scintigraphy was used to evaluate chan ges in myocardial perfusion after TMLR. Twelve patients underwent TMLR usin g a carbon dioxide laser. Sestamibi scans were carried out following a stan dard protocol prior to and 1, 3, 6, and 12 months after TMLR. Both visual a nd semi-quantitative assessment showed improvement in 4 patients, deteriora tion in 2 patients, and no change in the remaining 6 patients each. However , visual and semi-quantitative assessment were concordant in 6 patients and discordant in 6 patients. In 3 of these, semi-quantitative assessment sugg ested a better outcome, and in 3 patients visual assessment gave better res ults. Our findings in a small group of patients suggest that about a third benefited from TMLR. Gated myocardial perfusion scintigraphy using techneti um-99m sestamibi is suitable for visual evaluation of changes in the lased area over time, but does not allow semi-quantitative evaluation in the pati ent population typically treated with TMLR. Further investigations using op timized imaging protocols, including positron emission tomography and three dimensional image presentation, are warranted.