Two new withanolides from the aerial parts of Datura innoxia

Authors
Siddiqui, BS Afreen, S Begum, S
Citation
Bs. Siddiqui et al., Two new withanolides from the aerial parts of Datura innoxia, AUST J CHEM, 52(9), 1999, pp. 905-907
Citations number
10
Categorie Soggetti
Chemistry
Journal title
AUSTRALIAN JOURNAL OF CHEMISTRY
ISSN journal
00049425 → ACNP
Volume
52
Issue
9
Year of publication
1999
Pages
905 - 907
Database
ISI
SICI code
0004-9425(1999)52:9<905:TNWFTA>2.0.ZU;2-6
Abstract
Two new steroidal lactones of the withanolide group named as withametelinol (1a) and withametelinone (2) have been isolated from the aerial parts of D atura innoxia along with withametelin. The structures of the new constituen ts have been established as (20R,22R)-21,24-epoxy-12 alpha-hydroxy-1-oxowit ha-2,5,25(27)-trienolide and (20R,22R)-21,24-epoxy-1,12-dioxowitha-2,5,25(2 7)-trienolide through spectroscopic studies including one- and two-dimensio nal (COSY-45, NOESY, HMQC, HMBC) n.m.r. spectroscopy and chemical transform ations.