Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A newclass of anti-HIV agents

Authors
Hagihara, M Kashiwase, H Katsube, T Kimura, T Komai, T Momota, K Ohmine, T Nishigaki, T Kimura, S Shimada, K
Citation
M. Hagihara et al., Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A newclass of anti-HIV agents, BIOORG MED, 9(21), 1999, pp. 3063-3068
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
21
Year of publication
1999
Pages
3063 - 3068
Database
ISI
SICI code
0960-894X(19991101)9:21<3063:SAAAOA>2.0.ZU;2-L
Abstract
Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoro quinolones are reported. In the SAR study, the aryl substituents on the pip erazine nitrogen were found to play an important role for the anti-HIV-1 ac tivity. A few of the compounds exhibited potent anti-HIV activity: IC50 = 0 .06 mu M in chronically infected cells. (C) 1999 Elsevier Science Ltd. All rights reserved.