M. Hagihara et al., Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A newclass of anti-HIV agents, BIOORG MED, 9(21), 1999, pp. 3063-3068
Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoro
quinolones are reported. In the SAR study, the aryl substituents on the pip
erazine nitrogen were found to play an important role for the anti-HIV-1 ac
tivity. A few of the compounds exhibited potent anti-HIV activity: IC50 = 0
.06 mu M in chronically infected cells. (C) 1999 Elsevier Science Ltd. All
rights reserved.