Convenient synthesis of L-proline benzyl ester

Authors
Cordova, A Reed, NN Ashley, JA Janda, KD
Citation
A. Cordova et al., Convenient synthesis of L-proline benzyl ester, BIOORG MED, 9(21), 1999, pp. 3119-3122
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
21
Year of publication
1999
Pages
3119 - 3122
Database
ISI
SICI code
0960-894X(19991101)9:21<3119:CSOLBE>2.0.ZU;2-J
Abstract
Mesylates or tosylates of delta-hydroxy-L-norvaline esters spontaneously af ford L-proline esters upon exposure to aqueous buffer in near quantitative yield. This novel reaction has led to the development of a simple route to optically active proline esters. (C) 1999 Elsevier Science Ltd. All rights reserved.