Chlorophenylmethyl benzothiadiazine dioxides derivatives: Potent human cytomegalovirus inhibitors

Authors
Martinez, A Gil, C Perez, C Castro, A Prieto, C Otero, J
Citation
A. Martinez et al., Chlorophenylmethyl benzothiadiazine dioxides derivatives: Potent human cytomegalovirus inhibitors, BIOORG MED, 9(21), 1999, pp. 3133-3136
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
21
Year of publication
1999
Pages
3133 - 3136
Database
ISI
SICI code
0960-894X(19991101)9:21<3133:CBDDPH>2.0.ZU;2-8
Abstract
Modifications of our previously reported lead compounds, acyclonucleosides derived from 2,1,3-benzothiadiazine dioxides, in the search for inhibitors of human cytomegalovirus (HCMV), lead us to identify the chlorophenylmethyl benzothiadiazine dioxides derivatives as potent HCMV inhibitors. The synth esis and antiviral data of this second-generation of benzothiadiazine dioxi de compounds are reported. (C) 1999 Elsevier Science Ltd. All rights reserv ed.