Piperidinylpyrroles: Design, synthesis and binding properties of novel andselective dopamine D4 receptor ligands

Authors
Haubmann, C Hubner, H Gmeiner, P
Citation
C. Haubmann et al., Piperidinylpyrroles: Design, synthesis and binding properties of novel andselective dopamine D4 receptor ligands, BIOORG MED, 9(21), 1999, pp. 3143-3146
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
21
Year of publication
1999
Pages
3143 - 3146
Database
ISI
SICI code
0960-894X(19991101)9:21<3143:PDSABP>2.0.ZU;2-7
Abstract
Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knor r reaction. For the introduction of pyrrole-substituents high yielding tran sformations including Sonogashira cross-coupling reactions were utilized. E mployment of the reagent TosMIC gave access to the regioisomeric oxazolyl d erivatives 7 and 11 which showed the highest dopamine D4 receptor binding o f the series investigated. (C) 1999 Elsevier Science Ltd. All rights reserv ed.