Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues

Authors
De Jonghe, S Van Overmeire, I Gunst, J De Bruyn, A Hendrix, C Van Calenbergh, S Busson, R De Keukeleire, D Philippe, J Herdewijn, P
Citation
S. De Jonghe et al., Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues, BIOORG MED, 9(21), 1999, pp. 3159-3164
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
21
Year of publication
1999
Pages
3159 - 3164
Database
ISI
SICI code
0960-894X(19991101)9:21<3159:SAAAOF>2.0.ZU;2-2
Abstract
Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-ser ine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cel l lines and compared with their hydroxylated counterparts. (C) 1999 Elsevie r Science Ltd. All rights reserved.