Selective inhibition of low affinity IgE receptor (CD23) processing: P-1' bicyclomethyl substituents

Authors
Bailey, S Bolognese, B Faller, A Louis-Flamberg, P MacPherson, DT Mayer, RJ Marshall, LA Milner, PH Mistry, J Smith, DG Ward, JG
Citation
S. Bailey et al., Selective inhibition of low affinity IgE receptor (CD23) processing: P-1' bicyclomethyl substituents, BIOORG MED, 9(21), 1999, pp. 3165-3170
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
21
Year of publication
1999
Pages
3165 - 3170
Database
ISI
SICI code
0960-894X(19991101)9:21<3165:SIOLAI>2.0.ZU;2-B
Abstract
Using a variety of alpha-hydroxy hydroxamic acid derivatives, the size and shape of the S-1' pocket for the CD23 processing metalloprotease has been e xplored. It has been demonstrated that a P-1' 2-naphthylmethyl group occupi es most of the available space and gives excellent selectivity against fibr oblast collagenase (matrix metalloproteinase-1, MMP-1) and other MMPs. (C) 1999 Elsevier Science Ltd. All rights reserved.