Ab. Chikosi et al., 5,10 methylenetetrahydrofolate reductase polymorphism in black South African women with pre-eclampsia, BR J OBST G, 106(11), 1999, pp. 1219-1220
The polymorphic C677T mutation in the gene encoding 5,10 methylenetetrahydr
ofolate reductase has been shown to be a risk factor for pre-eclampsia in J
apanese and European women when inherited as a homozygous trait. We attempt
ed to verify these findings in a black African population with a high incid
ence of pre-eclampsia. No difference in frequency of the T-allele was obser
ved in 105 women with preeclampsia, compared with 110 healthy pregnant norm
otensive women. Only one woman with pre-eclampsia was TT homozygous, sugges
ting that methylenetetrahydrofolate reductase polymorphism is not an import
ant factor in the pathogenesis of pre-eclampsia in black South African wome
n.