Purpose: To compared the clinical efficacy of tramadol and morphine using a
patient-controlled analgesia (PCA) delivery system,
Methods: In a prospective, randomized, double blind study, we evaluated 80
adult patients scheduled for elective hip or knee arthroplasty with general
inhalational anesthesia. When patients complained of pain in the recovery
room, patients were randomized to receive either tramadol or morphine by ti
tration in 30 min to achieve analgesia (VAS less than or equal to 4), Equiv
alent volumes containing either 30 mg.ml(-1) tramadol or 1 mg.ml(-1) morphi
ne were used for PCA with a lockout interval of 10 min. The patients were f
ollowed six-hourly for 48 hr for VAS, satisfaction rate, analgesic dose, an
d side effects.
Results: Patients obtained adequate analgesia with either drug. More patien
ts had very good satisfaction scores in the morphine group in the recovery
room (43% vs 23%, P < 0.05) and at 24 hr (40% vs 20%, P < 0.05) than those
in the tramadol group. More nausea was evident in the tramadol group (48% v
s 11% in recovery room and 28% vs 12% in 24 hr, P < 0.05) than in the morph
ine group. Vomiting was also more (28% vs 5% in recovery room; 15% vs 3% in
24 hr, P < 0.05). Morphine produced more sleepiness (45% vs 23% in recover
y room, P < 0.05 and 35% vs 15% in 24 hr, P < 0.05).
Conclusion: Tramadol PCA can provide effective analgesia following major or
thopedic surgery provided sufficiently high doses are given for loading and
by patient demand. However, the incidence of nausea/vomiting is also highe
r causing decreased satisfaction.