Comparison of patient-controlled analgesia (PCA) with tramadol or morphine

Citation
Ww. Pang et al., Comparison of patient-controlled analgesia (PCA) with tramadol or morphine, CAN J ANAES, 46(11), 1999, pp. 1030-1035
Citations number
18
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
ISSN journal
0832610X → ACNP
Volume
46
Issue
11
Year of publication
1999
Pages
1030 - 1035
Database
ISI
SICI code
0832-610X(199911)46:11<1030:COPA(W>2.0.ZU;2-C
Abstract
Purpose: To compared the clinical efficacy of tramadol and morphine using a patient-controlled analgesia (PCA) delivery system, Methods: In a prospective, randomized, double blind study, we evaluated 80 adult patients scheduled for elective hip or knee arthroplasty with general inhalational anesthesia. When patients complained of pain in the recovery room, patients were randomized to receive either tramadol or morphine by ti tration in 30 min to achieve analgesia (VAS less than or equal to 4), Equiv alent volumes containing either 30 mg.ml(-1) tramadol or 1 mg.ml(-1) morphi ne were used for PCA with a lockout interval of 10 min. The patients were f ollowed six-hourly for 48 hr for VAS, satisfaction rate, analgesic dose, an d side effects. Results: Patients obtained adequate analgesia with either drug. More patien ts had very good satisfaction scores in the morphine group in the recovery room (43% vs 23%, P < 0.05) and at 24 hr (40% vs 20%, P < 0.05) than those in the tramadol group. More nausea was evident in the tramadol group (48% v s 11% in recovery room and 28% vs 12% in 24 hr, P < 0.05) than in the morph ine group. Vomiting was also more (28% vs 5% in recovery room; 15% vs 3% in 24 hr, P < 0.05). Morphine produced more sleepiness (45% vs 23% in recover y room, P < 0.05 and 35% vs 15% in 24 hr, P < 0.05). Conclusion: Tramadol PCA can provide effective analgesia following major or thopedic surgery provided sufficiently high doses are given for loading and by patient demand. However, the incidence of nausea/vomiting is also highe r causing decreased satisfaction.