H. Agata et al., Felypressin-induced reduction in coronary blood flow and myocardial tissueoxygen tension during anesthesia in dogs, CAN J ANAES, 46(11), 1999, pp. 1070-1075
Citations number
20
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
Purpose: To determine whether felypressin reduced myocardial tissue oxygen
tension (PmO2).
Methods: Seven open-chest dogs were studied under nitrous oxide and isoflur
ane anesthesia. Hemodynamic variables including heart rate (HR), blood pres
sure (BP), mean pulmonary arterial pressure (MPAP), PmO2 and coronary blood
flow (CBF) were continuously recorded. After baseline measurements felypre
ssin was infused at 0.15, 0.3, 0.6 and 1.0 IU.hr(-1) in a successive manner
. Hemodynamic variables were evaluated at 3, 6, 9 min after the start of ea
ch infusion.
Results: Felypressin caused reductions in CBF and inner layer PmO2 (int-PmO
2). Decreases in CBF (-23%, P < 0.05) and int-PmO2 (-8%, P < 0.05) observed
at low dose (0.151U.hr(-1)) were not accompanied by changes in BP and HR.
Negative correlations between cumulative doses of Felypressin (mlU.k(-1)) a
nd CBF (% change from base line) (r = -0.69, P < 0.05) or int-PmO2 (% chang
e from base line) (r = -0.48, P < 0.05) were observed.
Conclusion: Felypressin reduced PmO2 along with minimal changes in HR and B
P.