Beneficial effects of sevoflurane and desflurane against myocardial reperfusion injury after cardioplegic arrest

Purpose: To determine whether sevoflurane or desflurane offer additional pr otective effects against myocardial reperfusion injury after protecting the heart against the ischemic injury by cardioplegic arrest. Methods: Isolated rat hearts in a Langendorff-preparation (n=9) were arrest ed by infusion of HTK cardioplegic solution and subjected to 30 min global ischemia Followed by 60 min reperfusion (controls). An additional 18 hearts were subjected to the same protocol, and sevoflurane (n=9) or desflurane ( n=9) was added to the perfusion medium during the first 30 min of reperfusi on in a concentration corresponding to 1.5 MAC in rats, Left ventricular (L V) developed pressure and creatine kinase (CK) release were determined as i ndices of myocardial performance and cellular injury, respectively, Results: The LV developed pressure recovered to 46 +/- 7% of baseline in co ntrols. Functional recovery during reperfusion was improved by inhalational anesthetics to 67 +/- 3% (sevoflurane, P < 0.05) and 61 +/- 5% of baseline (desflurane, P < 0.05), respectively. Peak CK release during early reperfu sion was reduced from 52 +/- 11 U.min(-1).g(-1) in controls to 34 +/- 7 and 26 +/- 7 U.min(-1).g(-1) in sevoflurane and desflurane treated hearts, res pectively, The CK release during the first 30 min of reperfusion was reduce d From 312 +/- 41 U.g(-1) in control hearts to 195 +/- 40 and 206 +/- 37 U. g(-1) in sevoflurane and desflurane treated hearts, Conclusion: After ischemic protection by cardioplegia, sevoflurane and desf lurane given during the early reperfusion period offer additional protectio n against myocardial reperfusion injury.