Chronic myelomonocytic leukemia with t(7;11) (p15;p15) and NUP98/HOXA9 fusion

Translocation (7;11)(p15;p15) is a recently characterized chromosomal abnor mality that results in fusion of the NUP98 gene on 11p15 and the HOXA9 gene on 7p15. It shows a strong racial predisposition, being found predominantl y in Oriental patients, and has been reported almost exclusively in acute m yeloid leukemia, often with associated myelodysplastic changes. In this rep ort, rye describe the unique occurrence of t(7;11)(p15;p15) and NUP98/HOXA9 fusion in a patient with chronic myelomonocytic leukemia, and suggest that the genetic lesion may involve multipotential myeloid stem cells. (C) Else vier Science Inc., 1999. All rights reserved.