Cytogenetic and molecular characterization of a malignant mixed Mullerian tumor of the uterus with a t(8;22)(q24.1;q12)

Authors
Sreekantaiah, C Kwark, E Chuang, LT Ladanyi, M
Citation
C. Sreekantaiah et al., Cytogenetic and molecular characterization of a malignant mixed Mullerian tumor of the uterus with a t(8;22)(q24.1;q12), CANC GENET, 115(1), 1999, pp. 73-76
Citations number
25
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
115
Issue
1
Year of publication
1999
Pages
73 - 76
Database
ISI
SICI code
0165-4608(199911)115:1<73:CAMCOA>2.0.ZU;2-2
Abstract
We report the cytogenetic and molecular findings in a malignant mixed Mulle rian tumor of the uterus in a 65-year-old woman. Karyotypic analysis reveal ed a t(8;22)(q24.1;q12) as the sole abnormality in all 20 cells analyzed. S outhern blot analysis of two positional candidate genes, MYC at 8q24, and E WS at 22q12, showed no genomic rearrangement. The finding of the t(8;22) as the only abnormality may be of etiologic significance. (C) Elsevier Scienc e Inc., 1999. All rights reserved.