Relative avidities of human immunoglobulin G antibodies for streptococcal pyrogenic exotoxins A and B

Authors
Mascini, EM Jansze, M Verhoef, J van Dijk, H
Citation
Em. Mascini et al., Relative avidities of human immunoglobulin G antibodies for streptococcal pyrogenic exotoxins A and B, CL DIAG LAB, 6(6), 1999, pp. 977-980
Citations number
16
Categorie Soggetti
Immunology
Journal title
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
ISSN journal
1071412X → ACNP
Volume
6
Issue
6
Year of publication
1999
Pages
977 - 980
Database
ISI
SICI code
1071-412X(199911)6:6<977:RAOHIG>2.0.ZU;2-5
Abstract
In this pilot study, we investigated the relative avidities for streptococc al pyrogenic exotoxin A (SPE-A) and SPE-B of antibodies in sera from patien ts,vith fatal streptococcal toxic shock-like syndrome and from healthy indi viduals and in intravenous immunoglobulin (MG) preparations. We observed a great variation in the relative avidities of patient, control, and MG immun oglobulin G (IgG) (values estimated to be between 10(-7) and 10(-11) M), wi th mean values for patient IgG about 10-fold lower than those of control Ig G.