We studied immunoglobulin A production (IgA) in prostates of men with AIDS.
Prostate sections from AIDS patients and human immunodeficiency virus-nega
tive men were stained for IgA with immunoperoxidase. Prostate sections from
nondiseased men were positive for IgA, while prostate sections from AIDS p
atients were essentially negative for IgA. Diminishing secretory IgA produc
tion may represent a characteristic of AIDS.