The clinical spectrum of osteoarticular tuberculosis in non-human immunodeficiency virus patients in a defined area of northwestern Spain (1988-1997)

Objective To examine the frequency and clinical manifestations of osteoarticular tube rculosis in non-human immunodeficiency virus (HIV) patients during the past 10 years in a northwestern area of Spain. Methods The charts of all patients older than 14 years of age, not HIV-infected, an d diagnosed as having osteoarticular tuberculosis at the Xeral-Calde Hospit al from 1988 through 1997 were reviewed. All patients were residents of the region of Lugo. The diagnosis of osteoarticular tuberculosis was made on t he basis of a positive culture for Mycobacterium tuberculosis fi om synovia l fluid, joint tissue or paravertebral abscess or by histological findings of caseating granulomas in biopsied tissue. Results Thirty-two HIV-negative patients (20 men and 12 women) were diagnosed with osteoarticular tuberculosis. The average annual incidence rate of osteoarti cular tuberculosis in the combined (male and female) non-HIV population gre ater than or equal to 15 years of age was 15.68/million (95% CI: 10.25; 21. 11); males 20.02/million (95% CI: 11.25; 28.79); females 11.52/million (95% CI: 5.00; 18.03). The age at the time of diagnosis was 60.8 +/- 17.5 years . Peripheral monoarthritis was observed in 16 of the 32 cases. The knee was the most frequent site of peripheral tuberculous arthritis (31%), but invo lvement of the non-weight-bearing joints (50%) was also common. Spondylitis involving the lower thoracic and upper lumbar vertebrae (31%) and unilater al sacroiliitis (19%) were less commonly observed. In general, patients wit h osteoarticular tuberculosis had a long duration of symptoms of the diseas e prior to the diagnosis (median: 5.5 months). The tuberculin skin test was negative in 3 cases. Chest radiograph was abnormal in only 6 of 32 patient s (19%). The ESR (mean +/- SD) at the rime of diagnosis was 55.7 +/- 29.0 m m/hr. Computed tomography was very useful in detecting early involvement of the sacroiliac joints and in defining the extent of the abscesses and the severity of the involvement in patients with spondylitis. All patients rece ived chemotherapy for tuberculosis. None of them suffered relapses of tuber culosis. Conclusion Tuberculosis is a major source of osteoarticular complications in northwest ern Spain. The prevailing low level of clinical suspicion may explain the l ong delay to the diagnosis in most patients. A greater awareness of the pos sibility of this severe complication, especially in the elderly people or i n high-risk populations, would be advisable.