Multiple pathophysiologies for osteonecrosis have been postulated and vario
us associated risk factors defined for this disease. However, the pathologi
c findings of the end stage disease are thought to be similar in all patien
ts, To the author's knowledge, there are no data in the literature comparin
g the pathologic characteristics of osteonecrosis in a quantitative manner
between groups of patients with different associated risk factors. The curr
ent study examined the pathologic features of core decompression specimens
from the femoral head in a group of patients with osteonecrosis associated
with corticosteroid therapy and compared them with specimens from patients
with osteonecrosis with no history of corticosteroid therapy, The study gro
up comprised 65 patients (96 hips); 45 patients (68 hips) in the corticoste
roid group and 20 patients (28 hips) in the noncorticosteroid group. In the
corticosteroid group, 65% of dead bone was identified histologically (44 o
f 68) as compared with 46% (13 of 28) in the noncorticosteroid group. Speci
mens staged according to the histologic grading system of Arlet and Durroux
revealed the corticosteroid group had a higher incidence of late stage les
ions than did the noncorticosteroid group. This was found even though the t
wo groups had similar radiographic staging distribution. The hips in patien
ts who used alcohol were comparable pathologically to the hips in patients
who used corticosteroids, This study emphasizes that the histologic feature
s of necrosis and repair are similar in corticosteroid and noncorticosteroi
d osteonecrosis. However, there were differences in the distribution of via
ble bone and pathologic stage of the lesions in the two groups, suggesting
a more rapid evolution of changes in the corticosteroid group.