Atrial fibrillation (AF) is a common cardiac condition in the elderly popul
ation. The primary concern in individuals with AF is the risk of stroke. Th
e management of AF for stroke prevention requires an understanding of the r
elative risks and benefits of antithrombotic therapy. Numerous randomized c
linical trials have improved tremendously our understanding of the relative
merits of anticoagulation and aspirin, and indicate that anticoagulation i
s the appropriate treatment for the majority of individuals with AF. In pat
ients who have contraindications to anticoagulation, aspirin is recommended
.