No detected mutations in the genes for the amyloid precursor protein and presenilins 1 and 2 in a Swiss early-onset Alzheimer's disease family with adominant mode of inheritance

Mutations have been found in more than a hundred early-onset families with Alzheimer's disease (AD) in the genes for the amyloid precursor protein, pr esenilin 1 and presenilin 2. The object of our investigation was to identif y if these mutations or novel ones were operating in a Swiss early-onset AD family (mean age of onset: 53.3 years) with 7 members available, all neuro pathologically confirmed. No known or new mutations were detected. Thus, ou r data support the existence of a yet unknown mutation, or other genes, con tributing to familiar early onset AD. Copyright (C) 1999 S. Karger AG,Basel .