Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination

Authors
Taylor, MF Wiederholt, K Sverdrup, F
Citation
Mf. Taylor et al., Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination, DRUG DISC T, 4(12), 1999, pp. 562-567
Citations number
37
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DISCOVERY TODAY
ISSN journal
13596446 → ACNP
Volume
4
Issue
12
Year of publication
1999
Pages
562 - 567
Database
ISI
SICI code
1359-6446(199912)4:12<562:AOASHA>2.0.ZU;2-F
Abstract
Antisense technology provides a high-throughput and systematic approach to drug target validation and gene function discovery. In combination with oth er emerging technologies (such as microarrays), this technology will enable , efficient evaluation of the sequence data generated by the Human Genome P roject. The authors review recent advances in the antisense field and discu ss the potential use of antisense technology for functional genomics.