Perioperative clinical predictors of atrial fibrillation occurrence following coronary artery surgery

Objective: Atrial fibrillation (AF) is the most frequently encountered arrh ythmic complication associated with coronary surgery. The aim of this paper was then to identify the clinical predictors of post-CABG AF occurrence. M ethods: 150 consecutive patients were included in this study and divided in to two groups according to the absence (SR group, 104 male and 22 female, a ge 58.4 +/- s.g years) or presence (AF group, 23 male and 1 female, age 65. 4 +/- 6.3 years) of post-CABG AF. Forty-seven perioperative variables were considered. Results: After univariate analysis, advanced age (SR vs. AF: 58 .4 +/- 8.8 vs. 65.4 +/- 6.3, P < 0.001), an increased BMI (SR vs. AF: 26.1 +/- 2.7 vs. 27.4 +/- 2.5, P = 0.026), a prior history of paroxysmal AF (SR vs. AF: 3.2% vs. 16.7%, P = 0.028), left atrial enlargement (SR vs. AF: 21. 1% vs. 70.8%, P < 0.001) and a more severe coronary artery disease (CAD) (S R vs. AF: no. of diseased vessels: 2.42 +/- 0.7 vs. 2.91 +/- 0.3, P = 0.001 ; three-vessel CAD (54.1% vs. 91.3%, P = 0.002) were the only factors that statistically differed between the groups. Multivariate logistic regression analysis identified left atrial enlargement (P < 0.0001), a prior history of paroxysmal AF (P = 0.007) and a more severe CAD (P = 0.0047) to be indep endent correlates for AF. Conclusions: Post-CABG AF seems to require a well definite anatomical and electrical substrate that is generated by increase d left atrial dimensions, a greater extension of coronary lesions and a pos sible electrical remodeling consequent to prior repetitive episodes of paro xysmal AF. (C) 1999 Published by Elsevier Science B.V. All rights reserved.