Aspects of fetal thyroid dose following iodine-131 administration during early stages of pregnancy in patients suffering from benign thyroid disorders

Authors
Pauwels, EKJ Thomson, WH Blokland, JAK Schmidt, ME Bourguignon, M El-Maghraby, TAF Broerse, JJ Harding, LK
Citation
Ekj. Pauwels et al., Aspects of fetal thyroid dose following iodine-131 administration during early stages of pregnancy in patients suffering from benign thyroid disorders, EUR J NUCL, 26(11), 1999, pp. 1453-1457
Citations number
28
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
ISSN journal
03406997 → ACNP
Volume
26
Issue
11
Year of publication
1999
Pages
1453 - 1457
Database
ISI
SICI code
0340-6997(199911)26:11<1453:AOFTDF>2.0.ZU;2-8
Abstract
Detrimental effects on the thyroid of the developing fetus as a result of i odine-131 treatment for thyrotoxicosis of the mother in the first trimester of pregnancy are discussed. Dose estimations under typical clinical circum stances yield a fetal thyroid dose of 100-450 Sv. This dose may increase co nsiderably if the blood concentration of I-131 in the mother remains high. Under such circumstances there may be fetal thyroid dysfunction, which can lead to severe abnormalities.