Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects

Citation
O. Cekic et al., Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects, EYE, 13, 1999, pp. 656-659
Citations number
27
Categorie Soggetti
Optalmology
Journal title
EYE
ISSN journal
0950222X → ACNP
Volume
13
Year of publication
1999
Part
5
Pages
656 - 659
Database
ISI
SICI code
0950-222X(199910)13:<656:AHLOTA>2.0.ZU;2-1
Abstract
Purpose To evaluate aqueous humour levels of: topical 0.3% ciprofloxacin an d 0.3% ofloxacin in the same subjects, Methods Thirty-two bilateral cataractous patients received topical 0.3% cip rofloxacin in one eye and 0.3% ofloxacin in the other eye before each catar act extraction, Eyedrops were repetitively instilled for 6 h. Aqueous humou r samples were collected and assayed for drug concentrations by a method de scribed originally by us using high-performance liquid chromatography. Results Mean aqueous ciprofloxacin and ofloxacin levels were 0.33 +/- 0.04 mu g/ml (mean +/- SEM) and 1.34 +/- 0.14 mu g/ml respectively (p<0.0001). Conclusion Ofloxacin level in the aqueous humour is 4 times higher than tha t of ciprofloxacin in the same subjects.