Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes

Authors
Kirkiacharian, S Koutsourakis, PG Philibert, D Bouchoux, F Van de Velde, P
Citation
S. Kirkiacharian et al., Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes, FARMACO, 54(10), 1999, pp. 678-683
Citations number
28
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
54
Issue
10
Year of publication
1999
Pages
678 - 683
Database
ISI
SICI code
0014-827X(19991030)54:10<678:SARBAT>2.0.ZU;2-F
Abstract
The study of the relative binding affinity of a set of 2,3-disubstituted in denes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproli ferative effect on human MCF-7 cells also shows a weak activity for three d erivatives. (C) 1999 Elsevier Science S.A. All rights reserved.