Action of methanolic extract of mung bean hulls as inhibitors of lipid peroxidation and non-lipid oxidative damage

The antioxidant effects of methanolic extract of mung bean hulls (MEMBH) on lipids and non-lipids, including liposome, carbohydrate, protein and 2'-de oxyguanosine (2'-dG), were investigated. MEMBH exhibited a remarkable antio xidant effect in a liposome model system, indicating that the extract was a n inhibitor of lipid peroxidation. The inhibitory effect of MEMBH on deoxyr ibose damage was amount-dependent and it afforded considerable protection a gainst damage to deoxyribose. fn addition, MEMBH at low amounts was more ef fective in protecting protein oxidation. Furthermore, the oxidation of 2'-d G to 8-hydroxy-2'-deoxyguanosine (8-OH-2'dG) was inhibited by MEMBH. These results show that the extract also was an inhibitor of non-lipid oxidation damage. The extract exhibited metal binding ability and scavenging activity for hydrogen peroxide and hydroxyl radical, which may explain the mechanis m of their protecting lipids and non-lipids from oxidative damage. (C) 1999 Elsevier Science Ltd. All rights reserved.