Within the different kinds of dementia, Alzheimer's Disease (AD) obviously
is the only one showing relevant gender differences, concerning epidemiolog
y, risk factors and cognitive deficits. Women more often suffer from AD, ac
hieve lower Mini Mental Status Test scores when demented and show lower ver
bal skills. The possibility of using estrogen as a therapeutic agent, eithe
r only or as an augmentation to acetylcholinesterase inhibitors, could beco
me more important for clinical practice, as it is said to cause distinct im
provements of cognitive skills. Epidemiological studies were able to show t
hat estrogen replacement therapy in menopausal women lowers risk of AD.