Repetitive hydatidiform mole with different male partners

Citation
Zs. Tuncer et al., Repetitive hydatidiform mole with different male partners, GYNECOL ONC, 75(2), 1999, pp. 224-226
Citations number
17
Categorie Soggetti
Reproductive Medicine
Journal title
GYNECOLOGIC ONCOLOGY
ISSN journal
00908258 → ACNP
Volume
75
Issue
2
Year of publication
1999
Pages
224 - 226
Database
ISI
SICI code
0090-8258(199911)75:2<224:RHMWDM>2.0.ZU;2-V
Abstract
Objective. The aim of this study was to determine the role of parental fact ors that may relate to the pathogenesis of molar pregnancy. Methods. A retrospective review of six patients who had a molar pregnancy w ith at least two different partners at New England Trophoblastic Disease Ce nter between 1965 and March 1999 was performed. Results. A total of 34 pregnancies with 20 different partners were observed in 6 patients. These pregnancies resulted in 15 (44.1%) hydatidiform moles , 8 (23.5%) term live births, 7 (20.6%) therapeutic abortions, 3 (8.8%) spo ntaneous abortions, and 1 pre-term delivery, While 5 patients had a molar p regnancy with 2 different partners, 1 patient had a molar pregnancy with 3 different partners. Two patients developed persistent postmolar gestational trophoblastic tumor in 3 (20.0%) of the 15 episodes of molar pregnancy. Th ree of the male partners reported a total of 7 healthy children from prior relationships. Conclusion. The experience in these six patients suggests that a primary oo cyte problem may contribute to the development of molar pregnancy. (C) 1999 Academic Press.