Repetitive hydatidiform mole with different male partners

Objective. The aim of this study was to determine the role of parental fact ors that may relate to the pathogenesis of molar pregnancy. Methods. A retrospective review of six patients who had a molar pregnancy w ith at least two different partners at New England Trophoblastic Disease Ce nter between 1965 and March 1999 was performed. Results. A total of 34 pregnancies with 20 different partners were observed in 6 patients. These pregnancies resulted in 15 (44.1%) hydatidiform moles , 8 (23.5%) term live births, 7 (20.6%) therapeutic abortions, 3 (8.8%) spo ntaneous abortions, and 1 pre-term delivery, While 5 patients had a molar p regnancy with 2 different partners, 1 patient had a molar pregnancy with 3 different partners. Two patients developed persistent postmolar gestational trophoblastic tumor in 3 (20.0%) of the 15 episodes of molar pregnancy. Th ree of the male partners reported a total of 7 healthy children from prior relationships. Conclusion. The experience in these six patients suggests that a primary oo cyte problem may contribute to the development of molar pregnancy. (C) 1999 Academic Press.