A new series of 1-phenylpyrazole peptidomimetics

Authors
Santos, LMF Alves, AJ Brondani, DJ de Faria, AR Freitas, ACC de Lima, JG Leite, ACL
Citation
Lmf. Santos et al., A new series of 1-phenylpyrazole peptidomimetics, HETEROCYC C, 5(5), 1999, pp. 407-412
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLIC COMMUNICATIONS
ISSN journal
07930283 → ACNP
Volume
5
Issue
5
Year of publication
1999
Pages
407 - 412
Database
ISI
SICI code
0793-0283(1999)5:5<407:ANSO1P>2.0.ZU;2-G
Abstract
A facile and efficient method for the synthesis of a new series of 1-phenyl pyrazole peptidomimetics 6a-f is described. Peptide hand formation between the 1-phenylpyrazole unsaturated carboxylic acid and the amino acid residue has been achieved using benzotriazolyloxy-tris-(dimethylamino) phosphonium hexafluorophosphate (BOP) reagent and triethylamine (TEA). This strategy w as found to be successful for obtaining the pyrazole peptidomimetics.