Endometrial CD56+natural killer cells in women with recurrent miscarriage:a histomorphometric study

Endometrial natural killer (NK) cells were compared in luteal-phase endomet rial samples from women,vith recurrent miscarriage and from normal subjects . Cryostat sections were labelled using a monoclonal antibody to CD56 using an avidin-biotin complex method and a morphometric study performed. Increa sed mean numbers of CD56+ cells were documented in the endometrium of women with recurrent early miscarriage only. These findings suggest a possible r ole for NK cells in the pathogenesis of recurrent early pregnancy loss.