Diagnosis of Zollinger-Ellison syndrome. From symptoms to biological evidence

With insulinoma, Zollinger-Ellison syndrome is one of the most common funct ional islet-cell tumour. Since it is a life-threatening condition, needing appropriate management, the diagnosis must be accurately established This p aper reviews the clinical situations leading to suspect the diagnosis and t he biological tests, mainly the secretin test, that confirm the diagnosis. The different ways of performing the secretin test and the respective resul ts are presented. This review will also focus on some aspects of the diagno sis of multiple endocrine neoplasia type 1 in these patients.