Recovery from hepatitis C virus-positive cryoglobulinaemic glomerulonephritis after interferon therapy

The association between mixed cryoglobulinaemia and chronic hepatitis C vin ts infection has recently been described. Cryoglobulinaemic glomerulonephri tis, a complication of mixed cryoglobulinaemia, is usually treated with imm unosuppressive therapy, but, given the presence of viral infection, this th erapy is no longer recommended. This report concerns a case of a 30-year-ol d patient with cryoglobulinaemic glomerulonephritis, refractory to steroid treatment, in whom recovery from hepatitis C virus infection was obtained a s well as from cryoglobulinaemic glomerulonephritis after interferon therap y. The clinical symptoms and laboratory tests were normal after prolonged i nterferon therapy and, 3 years after the end of treatment, the patient is f ree from disease.