A pilot study of CPT-11 and cisplatin for ovarian clear cell adenocarcinoma

Background: Ovarian clear cell adenocarcinoma is known to have poorer progn osis than ovarian serous cystadenocarcinoma. Cyclophosphamide plus cisplati n has been the standard therapy for ovarian cancer, but ovarian clear cell adenocarcinoma dose not respond to this therapy. The treatment for ovarian clear cell adenocarcinoma has not been established. We planned a pilot stud y of CPT-11 and cisplatin for the treatment of ovarian clear cell adenocarc inoma. Methods: First, three patients were administered 70 mg/m(2) of cisplatin in travenously on day 1 and 60 mg/m2 of CPT-11 intravenously on days 1, 8 and 15. Treatment was repeated every 4 weeks. Other patients were administered 75 mg/m2 of cisplatin intraperitoneally on day 1 and 60 mg/m2 of CPT-11 int ravenously on days 1, 8 and 15. Treatment was repeated every 4 weeks. Results: A total of 10 patients were entered in this study and a total of 4 3 courses were administered. 1 CR, 1 PR and 1 PD were observed in patients with measurable lesion. Grade 3 leukopenia was experienced in seven patient s, grade 3 thrombocytopenia in two and grade 3 anemia in five. Grade 3 live r toxicity was observed in one patient and grade 3 diarrhea in one patient. No grade 4 toxicity was experienced. Conclusion: CPT-11 plus cisplatin is feasible and has efficacy for ovarian clear cell adenocarcinoma. This regimen should be explored in a phase II st udy.