Not only the total number of platelets but their normal or abnormal functio
n are essential points to be analyzed in case of stroke associated with thr
ombocytemia. When possible the treatment of arterial episodes in thrombocyt
emia should not be surgical. Anti-platelet agents and the rigourous control
of the different risk factors are warranted to limit the activation of abn
ormal platelets on early endothelial lesions and thereby limit the risk of
recurrent accidents. We report two typical cases illustrating these differe
nt points (J Mal Vasc 1999; 24: 300-302).