Preparation of 1-trifluoroacetyl indolizines and their derivatives via thecycloaddition of pyridinium N-ylides with 4-4-ethoxyl-1,1,1-trifluorobut-3-en-one

Authors
Zhu, SZ Qin, CY Wang, YL Chu, QL
Citation
Sz. Zhu et al., Preparation of 1-trifluoroacetyl indolizines and their derivatives via thecycloaddition of pyridinium N-ylides with 4-4-ethoxyl-1,1,1-trifluorobut-3-en-one, J FLUORINE, 99(2), 1999, pp. 183-187
Citations number
16
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF FLUORINE CHEMISTRY
ISSN journal
00221139 → ACNP
Volume
99
Issue
2
Year of publication
1999
Pages
183 - 187
Database
ISI
SICI code
0022-1139(199911)99:2<183:PO1IAT>2.0.ZU;2-M
Abstract
Under basic reaction conditions pyridinium or isoquinolinium N-ylides (C5H5 N+ CH2ETBr- or C9H7N+CH2YBr-, Y: CO2R, CN, PhCO) reacted readily with 4-eth oxyl-1,1,1-trifluorobut-3-en-2-one to give the corresponding I-trifluoroace tyl substituted indolizines or pyrrolo[1,2-a]isoquinolines. The molecular s tructure of 1-trifluoromethyl-3-methoxyl-pyrrolo-[1,2-a]isoquinoline is pre sented. (C) 1999 Elsevier Science S.A. All rights reserved.