Nucleic acid immunization: concepts and techniques associated with third generation vaccines

Authors
Hasan, UA Abai, AM Harper, DR Wren, BW Morrow, WJW
Citation
Ua. Hasan et al., Nucleic acid immunization: concepts and techniques associated with third generation vaccines, J IMMUNOL M, 229(1-2), 1999, pp. 1-22
Citations number
144
Categorie Soggetti
Immunology
Journal title
JOURNAL OF IMMUNOLOGICAL METHODS
ISSN journal
00221759 → ACNP
Volume
229
Issue
1-2
Year of publication
1999
Pages
1 - 22
Database
ISI
SICI code
0022-1759(19991029)229:1-2<1:NAICAT>2.0.ZU;2-D
Abstract
A radical change in vaccine methodology arrived nine years ago with the adv ent of nucleic acid immunization. Aspects such as plasmid design, gene sele ction, the use of immunostimulatory complexes and clinical trials are discu ssed in this review. Furthermore, concepts and protocols involved in the co nstruction, evaluation and immunization of a DNA vaccine have been examined as new strategies to enhance this technology continues to grow. (C) 1999 E lsevier Science B.V. All rights reserved.