Immunity to cross-reactive serotypes induced by pneumococcal conjugate vaccines in infants

Citation
Xh. Yu et al., Immunity to cross-reactive serotypes induced by pneumococcal conjugate vaccines in infants, J INFEC DIS, 180(5), 1999, pp. 1569-1576
Citations number
30
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00221899 → ACNP
Volume
180
Issue
5
Year of publication
1999
Pages
1569 - 1576
Database
ISI
SICI code
0022-1899(199911)180:5<1569:ITCSIB>2.0.ZU;2-W
Abstract
Infants were immunized with 1 of the 3 experimental pneumococcal conjugate vaccines that contain 6B and 19F but not 6A or 19A serotypes, Their sera we re studied for the capacity to opsonize Streptococcus pneumoniae 6A, 6B, 19 A, and 19F serotypes and the level of IgG antibody to the 4 serotypes, Sign ificant increases were observed in the number of infants with detectable op sonophagocytic titers with 3 conjugate vaccines for 6B (vaccine) serotype b ut with only 2 vaccines for 6A (cross-reactive) serotype, Significant incre ases were observed with 2 conjugate vaccines for 19F serotype but with only 1 vaccine for 19A serotype, Thus, some conjugate vaccines may elicit cross -protection better than others. In addition, correlations between opsonopha gocytic titers and IgG antibody levels by ELISA were high for 6B and 19F se rotypes but low for 6A and 19A serotypes, Thus, ELISA may be an inadequate surrogate assay of vaccine response for cross-reactive serotypes.