Effects of antigen dose and immunization regimens on antibody responses toa cytomegalovirus glycoprotein B subunit vaccine

Citation
Se. Frey et al., Effects of antigen dose and immunization regimens on antibody responses toa cytomegalovirus glycoprotein B subunit vaccine, J INFEC DIS, 180(5), 1999, pp. 1700-1703
Citations number
15
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00221899 → ACNP
Volume
180
Issue
5
Year of publication
1999
Pages
1700 - 1703
Database
ISI
SICI code
0022-1899(199911)180:5<1700:EOADAI>2.0.ZU;2-#
Abstract
The purpose of this phase I study was to evaluate the safety and immunogeni city of 2 doses of cytomegalovirus glycoprotein B (CMV gB)/MF59 vaccine at 3 different immunization schedules. Ninety-five volunteers were randomized to 6 groups. Antibodies to gB represent the majority of the CMV-specific ne utralizing response. Three groups received 5 mu g of gB antigen combined wi th MF59 (a proprietary adjuvant) and 3 groups received a 30-mu g dose at 0, 1, and 2 months; 0, 1, and 4 months; or 0, 1, and 6 months,The vaccine was well tolerated, and there was no significant difference in antibody produc tion between the 2 doses, The vaccine induced highest antibody titers when given at 0, 1, and 6 months. A low dose of CMV gB/ MF59 may be the preferre d dose for future studies.