Objective: The objective of this study was to determine the efficacy of Lac
tobacillus casei sps. rhamnosus (Lactobacillus GG) (LGG) in reducing the in
cidence of antibiotic-associated diarrhea when coadministered with an oral
antibiotic in children with acute infectious disorders.
Study design: Two hundred two children between 6 months and 10 years of age
were enrolled; 188 completed all phases of the protocol. LGG, 1 x 10(10) -
2 x 10(10) colony forming units per day, or comparable placebo was adminis
tered in a double-blind randomized trial to children receiving oral antibio
tic therapy in an outpatient setting. The primary caregiver was questioned
every 3 days regarding the incidence of gastrointestinal symptoms, predomin
antly stool frequency and consistency, through telephone contact by blinded
investigators.
Results: Twenty-five placebo-treated but only 7 LGG-treated patients had di
arrhea as defined by liquid stools numbering 2 or greater per day. Lactobac
illus GG overall significantly reduced stool frequency and increased stool
consistency during antibiotic therapy by the tenth day compared with the pl
acebo group.
Conclusion: Lactobacillus GG reduces the incidence of antibiotic-associated
diarrhea in children treated with oral antibiotics for common childhood in
fections.