Longitudinal assessment of hemoglobin oxygen saturation in healthy infantsduring the first 6 months

Limitations in home monitoring technology have precluded longitudinal studi es of hemoglobin oxygen saturation during unperturbed sleep. The memory mon itor used in the Collaborative Home Infant Monitoring Evaluation addresses these limitations. We studied 64 healthy term infants at 2 to 25 weeks of a ge. We analyzed hemoglobin oxygen saturation by purse oximetry (SpO(2)), re spiratory inductance plethysmography, heart rate, and sleep position during 35,127 epochs automatically recorded during the first 3 minutes of each ho ur. For each epoch baseline SpO(2) was determined during greater than or eq ual to 10 s of quiet breathing. Acute decreases of at least 10 saturation p oints and <90% for greater than or equal to 5 s were identified, and the lo west SpO(2) was noted. The median baseline SpO(2) was 97.9% and did not cha nge with age or sleep position. The baseline SpO(2) was <90% in at least I epoch in 59% of infants and in 0.51% of all. epochs. Acute decreases in SpO (2) occurred in 59% of infants; among these, the median number of episodes was 4. The median lowest SpO(2) during an acute decrease was 83% (10th, 90t h percentiles 78%, 87%); 79% of acute decreases were associated with period ic breathing, and greater than or equal to 16% were associated with isolate d apnea With the use of multivariate analyses, the odds of having an acute decrease increased as the number of epochs with periodic breathing increase d, and they lessened significantly with age. We conclude that healthy infan ts generally have baseline SpO(2) levels >95%. The transient acute decrease s are correlated with younger age, periodic breathing, and apnea and appear to be part of normal breathing and oxygenation behavior.