Chromatographic study of Re-186 complexes with various ligands

Thin-layer and paper chromatography have been used for the determination of radiochemical yields of Re-186 complexation with three selected ligands me thylenediphosphonic acid (MDP), ethylenediamminotetraacetic acid (EDTA), an d citrate convenient for the radiopharmaceutical applications. The combinat ion of selected two chromatographic systems has been chosen due to the sati sfactory separation of free perrhenate, corresponding complex with Re-186 a nd reduced hydrolyzed rhenium. Rhenium complexes with studied ligands were prepared by reduction of perrhenate at presence of suitable ligand. Stannou s chloride together with ascorbic acid (antioxidant) was used for perrhenat e reduction. The effect of pH of reaction mixture, reaction time and concen tration of reducing agent on the radiochemical yield of complexation is des cribed and the optimal conditions for synthesis of rhenium complexes with M DP, EDTA and citrate have been found. Under optimal condition the radiochem ical yield of complexation Re-186-MDP, Re-186-EDTA and Re-186-citrate reach ed more than 90%, 80%, and 80%, respectively.