Citation
Ro. Macedo et al., Application of thermogravimetry in the quality control of chloramphenicol tablets, J THERM ANA, 56(3), 1999, pp. 1323-1327
Citations number
7
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
ISSN journal
13886150
→ ACNP
Volume
56
Issue
3
Year of publication
1999
Pages
1323 - 1327
Database
ISI
SICI code
1388-6150(1999)56:3<1323:AOTITQ>2.0.ZU;2-3
Abstract
The stability and thermal behaviour of chloramphenicol and various of its m
ixtures were investigated. The thermogravimetric and stability constant res
ults showed that the chloramphenicol base is thermally more stable than the
tablet in the studied formulation. The reduction in stability was attribut
ed to the presence of search in the formulation. The thermal decompositions
of the chloramphenicol base and the tablet obey first-order kinetics.