Reporting bias in retrospective ascertainment of drug-induced embryopathy

Authors
Bar-Oz, B Moretti, ME Mareels, G Van Tittelboom, T Koren, G
Citation
B. Bar-oz et al., Reporting bias in retrospective ascertainment of drug-induced embryopathy, LANCET, 354(9191), 1999, pp. 1700-1701
Citations number
4
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
354
Issue
9191
Year of publication
1999
Pages
1700 - 1701
Database
ISI
SICI code
0140-6736(19991113)354:9191<1700:RBIRAO>2.0.ZU;2-J
Abstract
The rate of congenital malformations after first-trimester exposure to itra conazole was four times higher when ascertained retrospectively than prospe ctively (13.0 vs 3.2%, p = 0.006). Reporting bias in retrospective studies should be acknowledged in interpretation of such data.