Ion-exchange displacement chromatography: Scale-up and displacer clearancefor recombinant human brain-derived neurotrophic factor

Authors
Barnthouse, KA Trompeter, W Jones, R Rupp, R Cramer, SM
Citation
Ka. Barnthouse et al., Ion-exchange displacement chromatography: Scale-up and displacer clearancefor recombinant human brain-derived neurotrophic factor, LC GC, 17(11), 1999, pp. 1028
Citations number
8
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
LC GC-MAGAZINE OF SEPARATION SCIENCE
ISSN journal
08889090 → ACNP
Volume
17
Issue
11
Year of publication
1999
Database
ISI
SICI code
0888-9090(199911)17:11<1028:IDCSAD>2.0.ZU;2-M
Abstract
Because of toxicity concerns and a lack of relevant case studies, displacem ent chromatography has yet to be embraced by the biotechnology industry. Th is article is an example of a protein displacement process used at the pilo t scale.