Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans

Citation
H. Bruunsgaard et al., Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans, LIFE SCI, 65(24), 1999, pp. 2623-2633
Citations number
26
Categorie Soggetti
Biochemistry & Biophysics
Journal title
LIFE SCIENCES
ISSN journal
00243205 → ACNP
Volume
65
Issue
24
Year of publication
1999
Pages
2623 - 2633
Database
ISI
SICI code
0024-3205(19991105)65:24<2623:EIROLW>2.0.ZU;2-F
Abstract
This study was performed in order to investigate the type of T cells recrui ted to the blood in response to an acute bout of exercise with regard to me an lengths of telomeric terminal restriction fragments (TRF) and surface ac tivation markers and with special emphasis on age-associated differences. T en elderly and ten young humans performed maximal bicycle exercise. There w as no difference in the number of recruited CD4+ and CD8(+) cells between t he young and elderly group. In both age groups the immediate increases coul d be ascribed to recruitment of CD28(-) cells (CD8(+) and CD4(+) cells) and memory cells (only CD8+ cells). Furthermore, after exercise mean TRF lengt hs were significantly reduced in blood mononuclear cells and in CD8(+) cell s from young subjects and in CD4(+) cells from elderly subjects compared wi th lengths pre-exercise. These findings suggest that the mobilization of T lymphocytes during acute exercise is mainly a redistribution of previously activated cells with an increased replicative story than cells isolated fro m the blood at rest. Furthermore, elderly humans fulfilling the Senieur pro tocol have a preserved ability to recruit T lymphocytes in response to acut e physical stress.