Since 1942, when paracoccidioidomycosis was first identified in the state o
f Rio Grande do Sul, paracoccidioidal pulmonary lesions became a great conc
ern to physicians. The present study focuses on 53 patients diagnosed over
a seven-year period who presented paracoccidioidal lesions circumscribed to
the lungs. These patients presented clinical and radiological features tha
t simulated several pulmonary infectious and non-infectious conditions. Fou
r unusual cases are briefly discussed. A sequence of laboratorial tests sho
uld be established for the diagnosis of pulmonary paracoccidioidomycosis.