Labeling of zopiclone with iodine-131

Zopiclone (ZPC) was labeled with I-131 by using the halogen exchange method . Temperature and reaction time effects to labeling yields were studied, In frared, nuclear magnetic resonance, and gas chromatography-mass spectroscop y spectra were undertaken to identify chemical structure. High performance liquid chromatography (HPLC) was performed to determine purity of cold zopi clone. Biodistribution studies were performed on rabbits and rats. (131)IZP C was administered intravenously to rabbits. Static images were taken by a Sophy DX Gamma Camera. (131)IZPC was also administered intraperitoneally to rats. Activities were counted in a NaI(Tl) scintillation detector for seve ral organs (liver, brain, spleen, lung, blood, fat) after rats were decapit ated on different times. Biodistribution profiles were obtained depending o n the time. NUCL MED BIOL 26;7:827-831, 1999. (C) 1999 Elsevier Science Inc . All rights reserved.